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Discussion A milestone in our understanding of how the metabolic state of cells can be linked to cell survival and induction of cell death occurred ten years ago with the first description of ferroptosis 35,36,50
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19.2.7 Resistance to Targeted Agents: The Tyrosine Kinase Inhibitors The most widely used targeted drugs are small molecules, mostly derived from quinazoline, which act by inhibiting the kinase activity of oncogenes and/or growth factor receptors (see Chap
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